Cognitive & Neurological

Compounds studied in the nervous system, from learning and memory to nerve injury and stress signaling. Appearing here means a compound has been studied in this area, not that it works. Open a profile to see the type of evidence and its limits.

ACTH (1-39)

Endogenous 39-amino-acid pituitary peptide hormone derived from pro-opiomelanocortin (POMC); melanocortin-2 receptor (MC2R) agonist with activity at other melanocortin receptors; adrenal steroidogenesis stimulator

Adamax

Research-market synthetic peptide/peptidomimetic; purported modified Semax analogue; chemically incompletely standardized research compound

ARA-290

Synthetic 11-amino-acid erythropoietin-derived peptide; non-erythropoietic tissue-protective peptide; experimental innate-repair signaling agonist

B12

Essential water-soluble vitamin; cobalt-containing corrinoid cofactor; non-peptide micronutrient

Cerebrolysin

Porcine brain-derived peptide preparation; low-molecular-weight peptide mixture; neurotrophic drug preparation

Cortagen

Synthetic tetrapeptide; short peptide bioregulator; experimental neuroregulatory peptide

Delta Sleep-Inducing Peptide

Synthetic nonapeptide; experimental neuropeptide; sleep/stress-regulation research peptide

Dihexa

Synthetic angiotensin IV-derived peptidomimetic; HGF/c-Met modulator; experimental neurotrophic small molecule

Humanin

Mitochondrial-derived peptide (MDP); endogenous cytoprotective micropeptide associated with the mitochondrial 16S rRNA (MT-RNR2) region

Orexin-A

Endogenous 33-amino-acid hypothalamic neuropeptide; prepro-orexin (HCRT gene) product; dual orexin-receptor (OX1R/OX2R) agonist neuropeptide

Orexin-B

Endogenous 28-amino-acid linear hypothalamic neuropeptide; prepro-orexin (HCRT gene) product; orexin receptor 2 (OX2R)-preferring agonist neuropeptide

Oxytocin

Endogenous cyclic nonapeptide hormone; neuropeptide; oxytocin-receptor agonist

P21 (P021)

Synthetic adamantane-modified short peptidomimetic derived from ciliary neurotrophic factor (CNTF); experimental neurogenic/neurotrophic compound

PE-22-28

Synthetic heptapeptide; spadin-derived TREK-1 potassium-channel inhibitor; experimental antidepressant peptide

Pinealon

Synthetic tripeptide; short peptide bioregulator; experimental neuroprotective peptide

Selank

Synthetic heptapeptide; tuftsin analogue; glyproline peptide; experimental anxiolytic/neuropeptide

Semax

Synthetic heptapeptide; ACTH(4-7) analogue; melanocortin-derived neuropeptide; experimental neuroprotective/nootropic peptide