Metabolic Research

Compounds studied in energy balance, body weight, glucose handling and fat metabolism. Appearing here means a compound has been studied in this area, not that it works. Open a profile to see the type of evidence and its limits.

5-Amino-1MQ

Small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor; experimental metabolic compound

Adipotide

Synthetic targeted proapoptotic peptidomimetic; adipose-vasculature-targeting experimental compound

AICAR

Synthetic adenosine analog (nucleoside, not a peptide); cell-permeable precursor of ZMP, an AMP mimetic; AMP-activated protein kinase (AMPK) activator

AOD-9604

Synthetic modified C-terminal human growth hormone fragment; experimental metabolic peptide

B12

Essential water-soluble vitamin; cobalt-containing corrinoid cofactor; non-peptide micronutrient

Cagrilintide

Long-acting acylated amylin analogue; amylin and calcitonin receptor agonist

Dulaglutide

Long-acting glucagon-like peptide-1 (GLP-1) receptor agonist; recombinant fusion protein of two GLP-1 analog chains linked to a modified human IgG4 Fc fragment; once-weekly incretin therapy

Eloralintide

Long-acting selective amylin receptor agonist; preferential AMY1 receptor agonist

HGH (Somatropin)

Endogenous 191-amino-acid, 22-kDa pituitary polypeptide hormone; growth hormone receptor (GHR) agonist; approved recombinant hormone therapy

HGH Fragment 176-191

Synthetic C-terminal human growth hormone-derived peptide fragment; experimental metabolic peptide

IGF-1 DES

Naturally occurring truncated variant of insulin-like growth factor 1 lacking the N-terminal tripeptide Gly-Pro-Glu (67 amino acids); IGF-1 receptor agonist with markedly reduced IGF-binding-protein affinity

L-Carnitine

Endogenous quaternary ammonium compound; mitochondrial fatty-acid transport cofactor; conditionally essential nutrient

Lemon Bottle

Multi-ingredient commercial formulation; cosmetic/lipolysis-market product; non-peptide formulation

Lipo-C

Non-standardized multi-ingredient lipotropic formulation; nutrient/amino-acid blend; non-peptide formulation

Liraglutide

Long-acting acylated glucagon-like peptide-1 receptor (GLP-1R) agonist; GLP-1 analogue

Mazdutide

Long-acting peptide dual agonist of the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR)

MOTS-c

Mitochondrial-derived peptide (MDP); 16-amino-acid peptide encoded within mitochondrial DNA

Nicotinamide Adenine Dinucleotide

Endogenous nucleotide coenzyme; redox cofactor; metabolic signaling molecule

Orforglipron

Synthetic small-molecule (non-peptide) oral GLP-1 receptor agonist; partial, G protein-biased GLP-1R agonist; anti-obesity and antidiabetic agent

Pancragen

Synthetic tetrapeptide; insulinotropic-peptide mimetic; experimental pancreatic/endocrine bioregulator

Petrelintide

Long-acting amylin analogue; investigational amylin receptor agonist

Pramlintide

Synthetic amylin analogue; amylin receptor agonist; pancreatic hormone analogue

Retatrutide

Long-acting single-peptide triple agonist of the GIP, GLP-1, and glucagon receptors; investigational metabolic peptide

Semaglutide

Long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist; acylated GLP-1 analogue

SLU-PP-332

Synthetic small-molecule estrogen-related receptor pan-agonist; ERRα/β/γ agonist; experimental exercise-mimetic compound

Survodutide

Long-acting acylated peptide; dual glucagon receptor (GCGR) and GLP-1 receptor (GLP-1R) agonist

Tesamorelin

Synthetic growth hormone-releasing hormone (GHRH/GHRF) analogue; growth hormone secretagogue

Tirzepatide

Long-acting single-peptide dual agonist of the glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R)